Magnesium is one of the most essential minerals for nervous system health, muscle relaxation, and calm sleep. But not all magnesium supplements are created equal. If you’ve browsed supplements, you may have seen “magnesium glycinate” and “magnesium bisglycinate”—sometimes used interchangeably.
So, what’s the real story? And does the “bis” truly make a difference for achieving maximum calm?
In this article, we’ll explore the chemistry, absorption, and practical importance of magnesium bisglycinate versus simpler glycinate forms—and explain why CalmX utilizes the fully chelated bisglycinate form for superior, gentle support.
The Chemistry: What Do “Glycinate” and “Bisglycinate” Mean?
At a chemical level, both terms refer to magnesium bound (chelated) to the amino acid glycine. This chelation process makes the mineral more stable and easier for the body to absorb.
- Magnesium Glycinate: A general term for magnesium bound to glycine.
- Magnesium Bisglycinate: A more specific term indicating the magnesium ion is bound to two glycine molecules (from the prefix bis, meaning “twice”). This forms a stable, neutrally charged ring structure.
While chemically they refer to the same compound (magnesium diglycinate), in the world of high-quality supplements, “bisglycinate” is used to signify a fully chelated form. This ensures the magnesium is protected as it travels through the digestive system, leading to superior absorption.
The Absorption Advantage
The primary benefit of the bisglycinate form is its enhanced bioavailability. The dual-glycine structure allows it to be absorbed via amino acid pathways in the intestine, which are more efficient than the standard mineral ion channels.
This means:
- Protection from Inhibitors: The chelate structure protects the magnesium from binding with dietary factors (like phytates) that can block absorption.
- Increased Uptake: More elemental magnesium successfully passes from the intestine into the bloodstream.
Superior GI Tolerance
One of the most common complaints with magnesium supplements (especially oxide or citrate forms) is digestive discomfort. The bisglycinate form is renowned for its gentleness.
Because the chelate is absorbed intact, it doesn’t dissociate in the gut and cause the osmotic effect that leads to loose stools or cramping. This makes magnesium bisglycinate the ideal choice for sensitive individuals or those requiring higher doses for therapeutic effect.
Efficacy for Calm, Relaxation, and Sleep
Magnesium is critical for regulating the nervous system. It acts as a gatekeeper for NMDA receptors and enhances the calming effects of GABA. By delivering more usable magnesium to your cells, the bisglycinate form can more effectively support:
- Reduced Anxiety: By balancing neurotransmitters and calming the nervous system.
- Muscle Relaxation: Easing physical tension held in the body from stress.
- Improved Sleep Quality: Promoting deeper, more restorative sleep cycles.
The Final Word: Why CalmX Chooses Bisglycinate
While the terminology can be confusing, the science is clear: for maximum absorption, digestive comfort, and calming efficacy, the fully chelated bisglycinate form is superior.
CalmX is formulated with pure Magnesium Bisglycinate to ensure that every milligram is working to restore your body’s natural state of calm and balance—gently and effectively. The “bis” makes all the difference in delivering results you can truly feel.
References:
- Uwe Gröber, et al. (2017). Magnesium in Prevention and Therapy. Nutrients.
- DiNicolantonio, J. J., et al. (2018). Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis. Open Heart.
